Strategies to deliver peptide drugs to the brain
Lalatsa, Aikaterini and Schatzlein, Andreas G. and Uchegbu, Ijeoma F. (2014) Strategies to deliver peptide drugs to the brain. Molecular Pharmaceutics, 11 (4). pp. 1081-1093. ISSN 1543-8384 (https://doi.org/10.1021/mp400680d)
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Abstract
Neurological diseases such as neurodegeneration, pain, psychiatric disorders, stroke, and brain cancers would greatly benefit from the use of highly potent and specific peptide pharmaceuticals. Peptides are especially desirable because of their low inherent toxicity. The presence of the blood brain barrier (BBB), their short duration of action, and their need for parenteral administration limits their clinical use. However, over the past decade there have been significant advances in delivering peptides to the central nervous system. Angiopep peptides developed by Angiochem (Montreal, Canada), transferrin antibodies developed by ArmaGen (Santa Monica, USA), and cell penetrating peptides have all shown promise in delivering therapeutic peptides across the BBB after intravenous administration. Noninvasive methods of delivering peptides to the brain include the use of chitosan amphiphile nanoparticles for oral delivery and nose to brain strategies. The uptake of the chitosan amphiphile nanoparticles by the gastrointestinal epithelium is important for oral peptide delivery. Finally protecting peptides from plasma degradation is integral to the success of most of these peptide delivery strategies.
ORCID iDs
Lalatsa, Aikaterini ORCID: https://orcid.org/0000-0003-4791-7468, Schatzlein, Andreas G. and Uchegbu, Ijeoma F.;-
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Item type: Article ID code: 80820 Dates: DateEvent7 April 2014PublishedSubjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 19 May 2022 11:00 Last modified: 26 Sep 2024 01:20 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/80820