Multisystem inflammatory syndrome of a neonate from a COVID-19-infected mother : a case report

Malek, Abdul and Khadga, Mukesh and Zahid, Nurnobi and Mojib, Sanjida and Debnath, Reena and Khan, Seela and Haque, Mainul and Godman, Brian and Islam, Salequl (2022) Multisystem inflammatory syndrome of a neonate from a COVID-19-infected mother : a case report. Cureus, 14 (3). e23046. (

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In neonates, the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 – COVID-19) is lower. There is the potential for vertical transmission of SARS-CoV-2. To date, only a few reports suggest this possibility. Neonates usually have mild symptoms, but some develop multisystem involvement, which is a concern. COVID-19 infections have been reported both in pregnant women and their neonates. However, the evidence of vertical or horizontal transmission modes has not been fully established. We recorded a case study where a 33-year-old mother was tested positive for COVID-19 infection by RT-PCR during her 27th week of gestation and needed ventilator support for her respiratory distress at that time for 11 days. Subsequently, she gave birth to a female baby at the 35th week via a lower uterine segment cesarean section. The neonate manifested a severe multisystem inflammatory syndrome associated with her possible COVID-19 infection. Sharing her uncommon clinical presentation, immunological syndrome, and disease outcome are noteworthy for similar unforeseen pediatric case management to help guide future investigations and care