The potential for new and resilient anti-cancer drugs based upon minor groove binders for DNA
Scott, Fraser J. and Suckling, Colin J. (2021) The potential for new and resilient anti-cancer drugs based upon minor groove binders for DNA. Medical Research Archives, 9 (11). 2592. ISSN 2375-1924 (https://doi.org/10.18103/mra.v9i11.2592)
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Abstract
Anti-infective and anticancer drugs share the serious problem that over time resistance develops to their effects leading to clinical obsolescence. Research at the University of Strathclyde has discovered a platform of anti-infective drugs based upon minor groove binders for DNA that have exceptional resilience to the development of resistance in their target organisms (bacteria, fungi, and parasites). This property is associated with the fact that the Strathclyde minor groove binders (S-MGBs) act at more than one discrete molecular target. One of the compounds has successfully completed a phase IIa clinical trial for the treatment of Clostridioides difficile infections. Several other compounds have shown activity against a number of cancer cell lines in vitro with indications of in vivo activity in a mouse model of lung cancer. This paper places these discoveries in the context of previous studies of minor groove binders as anticancer agents and considers whether the benefits of multitargeting successfully demonstrated in anti-infective applications can be translated to anticancer applications.
ORCID iDs
Scott, Fraser J. ORCID: https://orcid.org/0000-0003-0229-3698 and Suckling, Colin J.;-
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Item type: Article ID code: 79037 Dates: DateEvent29 November 2021Published6 October 2021AcceptedNotes: This paper is open access. The publisher has incorrectly marked the license as 'All Rights Reserved', but an APC was paid for it to be CC-BY so it has been marked as such here. Subjects: Medicine > Internal medicine > Neoplasms. Tumors. Oncology (including Cancer)
Medicine > Therapeutics. PharmacologyDepartment: Faculty of Science > Pure and Applied Chemistry Depositing user: Pure Administrator Date deposited: 22 Dec 2021 14:17 Last modified: 12 Dec 2024 12:09 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/79037