Bilateral symmetry of linear streptomycete chromosomes
Algora-Gallardo, Lis and Schniete, Jana K. and Mark, David R. and Hunter, Iain S. and Herron, Paul R. (2021) Bilateral symmetry of linear streptomycete chromosomes. Microbial Genomics, 7 (11). ISSN 2057-5858 (https://doi.org/10.1099/mgen.0.000692)
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Abstract
Here, we characterize an uncommon set of telomeres from Streptomyces rimosus ATCC 10970, the parental strain of a lineage of one of the earliest-discovered antibiotic producers. Following the closure of its genome sequence, we compared unusual telomeres from this organism with the other five classes of replicon ends found amongst streptomycetes. Closed replicons of streptomycete chromosomes were organized with respect to their phylogeny and physical orientation, which demonstrated that different telomeres were not associated with particular clades and are likely shared amongst different strains by plasmid-driven horizontal gene transfer. Furthermore, we identified a ~50 kb origin island with conserved synteny that is located at the core of all streptomycete chromosomes and forms an axis around which symmetrical chromosome inversions can take place. Despite this chromosomal bilateral symmetry, a bias in parS sites to the right of oriC is maintained across the family Streptomycetaceae and suggests that the formation of ParB/parS nucleoprotein complexes on the right replichore is a conserved feature in streptomycetes. Consequently, our studies reveal novel features of linear bacterial replicons that, through their manipulation, may lead to improvements in growth and productivity of this important industrial group of bacteria.
ORCID iDs
Algora-Gallardo, Lis, Schniete, Jana K. ORCID: https://orcid.org/0000-0003-4274-5839, Mark, David R., Hunter, Iain S. ORCID: https://orcid.org/0000-0003-2571-6016 and Herron, Paul R. ORCID: https://orcid.org/0000-0003-3431-1803;-
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Item type: Article ID code: 78602 Dates: DateEvent15 November 2021Published14 September 2021Accepted27 May 2021SubmittedSubjects: Science > Natural history > Biology Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 17 Nov 2021 10:17 Last modified: 27 Nov 2024 21:24 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/78602