Ultrasensitive detection of ribonucleic acid biomarkers using portable sensing platforms based on organic electrochemical transistors

Fu, Ying and Wang, Naixiang and Yang, Anneng and Xu, Zhiai and Zhang, Wen and Liu, Hong and Law, Helen Ka-wai and Yan, Feng (2021) Ultrasensitive detection of ribonucleic acid biomarkers using portable sensing platforms based on organic electrochemical transistors. Analytical Chemistry, 93 (43). pp. 14359-14364. ISSN 0003-2700 (https://doi.org/10.1021/acs.analchem.1c03441)

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Abstract

The analysis of ribonucleic acid (RNA) plays an important role in the early diagnosis of diseases and will greatly benefit patients with a higher cure rate. However, the low abundance of RNA in physiological environments requires ultrahigh sensitivity of a detection technology. Here, we construct a portable and smart-phone-controlled biosensing platform based on disposable organic electrochemical transistors for ultrasensitive analysis of microRNA (miRNA) biomarkers within 1 h. Due to their inherent amplification function, the devices can detect miRNA cancer biomarkers from little-volume solutions with concentrations down to 10–14 M. The devices can distinguish blood miRNA expression levels at different cancer stages using a 4T1 mouse tumor model. The technique for ultrasensitive and fast detection of RNA biomarkers with high selectivity opens a window for mobile diagnosis of various diseases with low cost.

ORCID iDs

Fu, Ying ORCID logoORCID: https://orcid.org/0000-0002-8196-6493, Wang, Naixiang, Yang, Anneng, Xu, Zhiai, Zhang, Wen, Liu, Hong, Law, Helen Ka-wai and Yan, Feng;
  • Item type:Article
    ID code:78467
    Dates:
    Date
    Event
    2 November 2021
    Published
    18 October 2021
    Published Online
    13 October 2021
    Accepted
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:09 Nov 2021 12:12
    Last modified:11 Nov 2024 13:17
    URI:https://strathprints.strath.ac.uk/id/eprint/78467
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