Dye-free retinal angiography using blood-oxygenation modulation

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MacKenzie, L.E. and Choudhary, T.R. and Fernandez Ramos, J. and Benjamin, N. and Delles, C. and Harvey, A.R. (2018) Dye-free retinal angiography using blood-oxygenation modulation. Other. bioRxiv, New York. (https://doi.org/10.1101/485839)

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Abstract

Fluorescence angiography (FA) is widely used for studying and diagnosing abnormalities in the retinal blood circulation, but has associated risks of nausea, skin irritation, and even death. We describe a new non-invasive angiography technique: Blood Oxygenation Modulation Angiography, in which multispectral imaging of a transient perturbation in blood-oxygen saturation, yields angiography sequences similar to FA, including key features such as sequential filling of choroidal and retinal-vessels, which underpin assessment of circulation health. This is the first non-invasive angiography technique capable of visualizing these circulation features.

ORCID iDs

MacKenzie, L.E. ORCID logoORCID: https://orcid.org/0000-0002-8151-0525, Choudhary, T.R., Fernandez Ramos, J., Benjamin, N., Delles, C. and Harvey, A.R.;
CORE (COnnecting REpositories)