Spectroscopic oximetry in the eye : a review

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MacKenzie, Lewis. E. and Harvey, Andy. R. and McNaught, Andy. I. (2017) Spectroscopic oximetry in the eye : a review. Expert Review of Ophthalmology, 12 (4). pp. 345-356. ISSN 1746-9899 (https://doi.org/10.1080/17469899.2017.1318067)

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Abstract

Introduction: Non-invasive measurement of blood oxygen saturation via spectroscopic imaging has provided insights into ocular physiology and the development of a variety of ocular conditions, including retinal vascular occlusion, diabetic retinopathy and glaucoma. Major developments since the late 90s have been enabled by advancements in imaging technology, computational image analysis, and innovative experimental methods. Areas covered: We review the theory of spectroscopic oximetry, the ocular blood vessels targeted for oximetry, the imaging systems utilised, and methods to validate oximetry measures. We detail the main physiological and clinical insights provided by ocular oximetry. Expert commentary: Oximetry has revealed physiological norms and auto-regulatory effects in the retina, choroid, episcleral, and bulbar conjunctival blood vessels. Retinal oximetry has provided insights into the development of diabetic retinopathy and glaucoma, and may enhance the evaluation and treatment of retinal vessel occlusion. Commercially available retinal oximetry systems have enabled oximetry in the clinical setting. The development of more sophisticated phantoms that resemble in vivo environments has helped validate oximetry applications. New insights into ocular physiology and disease are likely to be gleaned from future studies.

ORCID iDs

MacKenzie, Lewis. E. ORCID logoORCID: https://orcid.org/0000-0002-8151-0525, Harvey, Andy. R. and McNaught, Andy. I.;
  • Item type:Article
    ID code:77958
    Dates:
    Date
    Event
    19 April 2017
    Published
    7 April 2017
    Accepted
    Subjects:Science > Physics
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:30 Sep 2021 13:50
    Last modified:11 Nov 2024 13:14
    URI:https://strathprints.strath.ac.uk/id/eprint/77958
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