Deficits in short-term memory binding are detectable in individuals with brain amyloid deposition in the absence of overt neurodegeneration in the Alzheimer's disease continuum

Cecchini, Mario Amore and Yassuda, Mônica Sanches and Squarzoni, Paula and Coutinho, Artur Martins and de Paula Faria, Daniele and de Souza Duran, Fábio Luiz and Antunes da Costa, Naomi and de Gobbi Porto, Fábio Henrique and Nitrini, Ricardo and Vicente Forlenza, Orestes and Dozzi Brucki, Sonia Maria and Buchpiguel, Carlos Alberto and Parra, Mario A. and Busatto, Geraldo F. (2021) Deficits in short-term memory binding are detectable in individuals with brain amyloid deposition in the absence of overt neurodegeneration in the Alzheimer's disease continuum. Brain and Cognition, 152. ISSN 0278-2626 (https://doi.org/10.1016/j.bandc.2021.105749)

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Abstract

The short-term memory binding (STMB) test involves the ability to hold in memory the integration between surface features, such as shapes and colours. The STMB test has been used to detect Alzheimer’s disease (AD) at different stages, from preclinical to dementia, showing promising results. The objective of the present study was to verify whether the STMB test could differentiate patients with distinct biomarker profiles in the AD continuum. The sample comprised 18 cognitively unimpaired (CU) participants, 30 mild cognitive impairment (MCI) and 23 AD patients. All participants underwent positron emission tomography (PET) with Pittsburgh compound-B labelled with carbon-11 ([11C]PIB) assessing amyloid beta (Aβ) aggregation (A) and 18fluorine-fluorodeoxyglucose ([18F]FDG)-PET assessing neurodegeneration (N) (A−N− [n = 35]); A+N− [n = 11]; A+ N+ [n = 19]). Participants who were negative and positive for amyloid deposition were compared in the absence (A−N− vs. A+N−) of neurodegeneration. When compared with the RAVLT and SKT memory tests, the STMB was the only cognitive task that differentiated these groups, predicting the group outcome in logistic regression analyses. The STMB test showed to be sensitive to the signs of AD pathology and may represent a cognitive marker within the AD continuum.

ORCID iDs

Cecchini, Mario Amore, Yassuda, Mônica Sanches, Squarzoni, Paula, Coutinho, Artur Martins, de Paula Faria, Daniele, de Souza Duran, Fábio Luiz, Antunes da Costa, Naomi, de Gobbi Porto, Fábio Henrique, Nitrini, Ricardo, Vicente Forlenza, Orestes, Dozzi Brucki, Sonia Maria, Buchpiguel, Carlos Alberto, Parra, Mario A. ORCID logoORCID: https://orcid.org/0000-0002-2412-648X and Busatto, Geraldo F.;
CORE (COnnecting REpositories)