Cytokine upregulation of proteinase-activated-receptors 2 and 4 expression mediated by p38 MAP kinase and inhibitory kappa B kinase ß in human endothelial cells

Ritchie, E. and Saka, M. and MacKenzie, C. and Drummond, R.M. and Wheeler-Jones, C. and Kanke, T. and Plevin, R.J. (2007) Cytokine upregulation of proteinase-activated-receptors 2 and 4 expression mediated by p38 MAP kinase and inhibitory kappa B kinase ß in human endothelial cells. British Journal of Pharmacology, 150. pp. 1044-1054. ISSN 1476-5381

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Abstract

Up-regulation of proteinase-activated receptor-2 (PAR2) is a factor in a number of disease states and we have therefore examined the signalling pathways involved in the expression of the receptor.