Functionalized main-group organometallics for organic synthesis

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Knochel, Paul and Hupe, Eike and Dohle, Wolfgang and Lindsay, David M. and Bonnet, Véronique and Quéguiner, Guy and Boudier, Andreas and Kopp, Felix and Demay, Stéphane and Seidel, Naka and Calaza, M. Isabel and Vu, Viet Anh and Sapountzis, Ioannis and Bunlaksananusorn, Tanasri (2002) Functionalized main-group organometallics for organic synthesis. Pure and Applied Chemistry, 74 (1). pp. 11-17. ISSN 1365-3075 (https://doi.org/10.1351/pac200274010011)

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Abstract

Highly functionalized Grignard-reagents can be easily obtained by an iodine–magnesium exchange reaction and further reacted with various electrophiles. Via a B–Zn exchange reaction, a formal Michael addition with umpolung of the reactivity can be achieved. Chiral phosphine ligands can be easily synthesized by a 2.3 sigmatropic rearrangement and used successfully in asymmetric synthesis.

ORCID iDs

Knochel, Paul, Hupe, Eike, Dohle, Wolfgang, Lindsay, David M. ORCID logoORCID: https://orcid.org/0000-0003-4498-5094, Bonnet, Véronique, Quéguiner, Guy, Boudier, Andreas, Kopp, Felix, Demay, Stéphane, Seidel, Naka, Calaza, M. Isabel, Vu, Viet Anh, Sapountzis, Ioannis and Bunlaksananusorn, Tanasri;
CORE (COnnecting REpositories)