Improving consistency for a Mefenamic acid immediate release formulation
Prasad, Elke and Robertson, John and Halbert, Gavin (2020) Improving consistency for a Mefenamic acid immediate release formulation. Journal of Pharmaceutical Sciences. ISSN 0022-3549 (In Press)
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Abstract
The objective of this study was to develop an immediate release dose form containing 250 mg Mefenamic acid (MFA) presented as a crystalline solid dispersion in order to achieve improved consistency in drug release through a simplified formulation compared to a commercial product. An MFA-Soluplus®-Sorbitol polymer matrix was developed using an HME process based on rheological screening assays of physical mixtures. The physico-chemical properties of these formulations were assessed by thermal analysis, FTIR, mechanical testing and SEM image analysis, confirming the crystalline character and stable polymorphic form I of the API in the polymer matrix. A faster release and a significant improvement in consistency (± 6 %) of drug release was observed compared to a commercially available MFA product (± 17 %) (250 mg capsule). This study illustrates advantages of applying a structured development program aimed at retaining API physical properties in the final dosage form.
Creators(s): |
Prasad, Elke ![]() ![]() | Item type: | Article |
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ID code: | 73660 |
Keywords: | extrusion, solid dosage form, oral drug delivery, solid dispersion, dissolution, formulation, Pharmacy and materia medica, Pharmacology, Toxicology and Pharmaceutics(all) |
Subjects: | Medicine > Pharmacy and materia medica |
Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Technology and Innovation Centre > Continuous Manufacturing and Crystallisation (CMAC) |
Depositing user: | Pure Administrator |
Date deposited: | 20 Aug 2020 10:13 |
Last modified: | 17 Dec 2020 02:52 |
Related URLs: | |
URI: | https://strathprints.strath.ac.uk/id/eprint/73660 |
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