UV-induced 1,3,4-oxadiazole formation from 5-substituted tetrazoles and carboxylic acids in flow

Green, Luke and Livingstone, Keith and Bertrand, Sophie and Peace, Simon and Jamieson, Craig (2020) UV-induced 1,3,4-oxadiazole formation from 5-substituted tetrazoles and carboxylic acids in flow. Chemistry - A European Journal. ISSN 0947-6539 (In Press)

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    Abstract

    A range of 1,3,4-oxadiazoles have been synthesized using a UV-B activated flow approach starting from carboxylic acids and 5-substituted tetrazoles. The application of UV light represents an attractive alternative to the traditional thermolytic approach and has demonstrated comparable efficiency and versatility, with a diverse substrate scope, including the incorporation of highly substituted amino acids.