UV-induced 1,3,4-oxadiazole formation from 5-substituted tetrazoles and carboxylic acids in flow

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Green, Luke and Livingstone, Keith and Bertrand, Sophie and Peace, Simon and Jamieson, Craig (2020) UV-induced 1,3,4-oxadiazole formation from 5-substituted tetrazoles and carboxylic acids in flow. Chemistry - A European Journal, 26 (65). pp. 14866-14870. ISSN 1521-3765 (https://doi.org/10.1002/chem.202002896)

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Abstract

A range of 1,3,4-oxadiazoles have been synthesized using a UV-B activated flow approach starting from carboxylic acids and 5-substituted tetrazoles. The application of UV light represents an attractive alternative to the traditional thermolytic approach and has demonstrated comparable efficiency and versatility, with a diverse substrate scope, including the incorporation of highly substituted amino acids.

ORCID iDs

Green, Luke, Livingstone, Keith, Bertrand, Sophie, Peace, Simon and Jamieson, Craig ORCID logoORCID: https://orcid.org/0000-0002-6567-8272;
CORE (COnnecting REpositories)