Magnetic nanoparticles for enhancing the effectiveness of ultrasonic hyperthermia

Józefczak, A. and Kaczmarek, K. and Hornowski, T. and Kubovcikov, M. and Rozynek, Z. and Timko, M. and Skumiel, A. (2016) Magnetic nanoparticles for enhancing the effectiveness of ultrasonic hyperthermia. Applied Physics Letters, 108. 263701. ISSN 0003-6951

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    Abstract

    Ultrasonic hyperthermia is a method of cancer treatment in which tumors are exposed to an elevated cytotoxic temperature using ultrasound (US). In conventional ultrasonic hyperthermia, the ultrasound-induced heating in the tumor is achieved through the absorption of wave energy. However, to obtain appropriate temperature in reasonable time, high US intensities, which can have a negative impact on healthy tissues, are required. The effectiveness of US for medical purposes can be significantly improved by using the so-called sonosensitizers, which can enhance the thermal effect of US on the tissue by increasing US absorption. One possible candidate for such sonosensitizers is magnetic nanoparticles with mean sizes of 10–300 nm, which can be efficiently heated because of additional attenuation and scattering of US. Additionally, magnetic nanoparticles are able to produce heat in the alternating magnetic field (magnetic hyperthermia). The synergetic application of ultrasonic and magnetic hyperthermia can lead to a promising treatment modality.

    Creators(s): Józefczak, A., Kaczmarek, K. ORCID logoORCID: https://orcid.org/0000-0002-3193-0070, Hornowski, T., Kubovcikov, M., Rozynek, Z., Timko, M. and Skumiel, A.;
    Item type:Article
    ID code:71880
    Notes:This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Appl. Phys. Lett. 108, 263701 (2016) and may be found at https://doi.org/10.1063/1.4955130
    Keywords:thermal instruments, cancer treatment, ultrasonic hyperthermia, ultrasonics, ultrasound, nanopartIcles, magnetic fields, Physics, Medicine, Physics and Astronomy (miscellaneous), Medicine(all)
    Subjects:Science > Physics
    Medicine
    Department:Faculty of Engineering > Biomedical Engineering
    Depositing user: Pure Administrator
    Date deposited:26 Mar 2020 09:13
    Last modified:21 Jan 2021 11:48
    URI:https://strathprints.strath.ac.uk/id/eprint/71880
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