Unexpected Dealkylation During Nucleophilic Substitution: Synthesis of 2-N,N-Dialkylamino Benzoxazoles and Benzothiazoles

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Khalaf, A.I. and Alvarez, R.G. and Suckling, C.J. and Waigh, R.D. (2000) Unexpected Dealkylation During Nucleophilic Substitution: Synthesis of 2-N,N-Dialkylamino Benzoxazoles and Benzothiazoles. Tetrahedron, 56 (43). pp. 8567-8571. ISSN 0040-4020 (http://dx.doi.org/10.1016/S0040-4020(00)00802-4)

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Abstract

Mild reaction conditions are described for the preparation of a number of 2-alkyl- and 2-arylaminobenzoxazoles and benzothiazoles from 2-chlorobenzoxazole and 2-chlorobenzothiazole and N-methyl or other simple N-alkyl tertiary amines. The reaction proceeds neat or in THF solution and involves dealkylation of the amine reactant by nucleophilic substitution by chloride. In the case of N-methylpyrrolidine and N-methylpiperidine demethylation was not observed and the major product was formed by ring opening to give chlorobutyl- and chloropentyl-methylamino substituted benzoxazoles and benzothiazoles. Treatment of the chlorobutyl derivative with iodide in acetone afforded the new 1H,2H,3H,4H,5H-[1,3]diazepino[2,1-b][1,3]benzoxazol-6-ium ring system.

ORCID iDs

Khalaf, A.I. ORCID logoORCID: https://orcid.org/0000-0001-9162-7527, Alvarez, R.G., Suckling, C.J. and Waigh, R.D.;
CORE (COnnecting REpositories)