Pattern of inappropriate antibiotic use among hospitalized patients in Pakistan : a longitudinal surveillance and implications

Saleem, Zikria and Saeed, Hamid and Hassali, Mohamed Azmi Ahmad and Godman, Brian and Asif, Usama and Yousaf, Mahrukh and Ahmed, Zakiuddin and Riaz, Humayun and Raza, Syed Atif (2019) Pattern of inappropriate antibiotic use among hospitalized patients in Pakistan : a longitudinal surveillance and implications. Antimicrobial Resistance and Infection Control, 8. 188. ISSN 2047-2994 (https://doi.org/10.1186/s13756-019-0649-5)

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Abstract

Background: The inappropriate use of antibiotics in hospitals increases resistance, morbidity, and mortality. Little is currently known about appropriate antibiotic use among hospitals in Lahore, the capital city of Pakistan. Methods: Longitudinal surveillance was conducted over a period of two months among hospitals in Lahore, Pakistan. Antibiotic treatment was considered inappropriate on the basis of a wrong dosage regimen, wrong indication, or both based on the British National Formulary. Results: A total of 2022 antibiotics were given to 1185 patients. Out of the total prescribed, approximately two-thirds of the study population (70.3%) had at least one inappropriate antimicrobial. Overall, 27.2% of patients had respiratory tract infections, and out of these, 62.8% were considered as having inappropriate therapy. Cephalosporins were extensively prescribed among patients, and in many cases, this was inappropriate (67.2%). Penicillins were given to 283 patients, out of which 201 (71.0%) were prescribed for either the wrong indication or dosage or both. Significant variations were also observed regarding inappropriate prescribing for several antimicrobials including the carbapenems (70.9%), aminoglycosides (35.8%), fluoroquinolones (64.2%), macrolides (74.6%) and other antibacterials (73.1%). Conclusion: Educational interventions, institutional guidelines, and antimicrobial stewardship programs need to be developed to enhance future appropriate antimicrobial use in hospitals in Pakistan. Policies by healthcare and Government officials are also needed to minimize inappropriate antibiotic use.

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