Biocatalytic ATRP in solution and on surfaces

Rodriguez, Kyle J. and Pellizzoni, Michela M. and Divandari, Mohammad and Benetti, Edmondo M. and Bruns, Nico; Bruns, Nico and Loos, Katja, eds. (2019) Biocatalytic ATRP in solution and on surfaces. In: Methods in Enzymology. Methods in Enzymology, 627 . Academic Press Inc., Cambridge, MA, pp. 263-290. ISBN 9780128170953 (

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The promiscuity of enzymes allows for their implementation as catalysts for non-native chemical transformations. Utilizing the redox activity of metalloenzymes under activator regenerated by electron transfer (ARGET) ATRP conditions, well-controlled and defined polymers can be generated. In this chapter, we review bioATRP in solution and on surfaces and provide experimental protocols for hemoglobin-catalyzed ATRP and for surface-initiated biocatalytic ATRP. This chapter highlights the polymerization of acrylate and acrylamide monomers and provides detailed experimental protocols for the characterization of the polymers and of the polymer brushes.


Rodriguez, Kyle J., Pellizzoni, Michela M., Divandari, Mohammad, Benetti, Edmondo M. and Bruns, Nico ORCID logoORCID:; Bruns, Nico and Loos, Katja