Anti-tumor activity of intravenously administered plumbagin entrapped in targeted nanoparticles

Sakpakdeejaroen, Intouch and Somani, Sukrut and Laskar, Partha and Irving, Craig and Mullin, Margaret and Dufes, Christine (2019) Anti-tumor activity of intravenously administered plumbagin entrapped in targeted nanoparticles. Journal of Biomedical Nanotechnology. ISSN 1550-7033 (In Press)

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Abstract

Plumbagin, a naphthoquinone extracted from the officinal leadwort, has recently been shown to exert promising anti-cancer effects. However, its therapeutic use is hampered by its failure to specifically reach tumors after intravenous administration, without secondary effects on normal tissues. Its poor aqueous solubility and rapid elimination in vivo further limit its potential use. We hypothesize that the entrapment of plumbagin within PEGylated PLGA nanoparticles conjugated with transferrin, whose receptors are overexpressed on many cancer cells, could result in a selective delivery to tumors following intravenous administration and enhance its chemotherapeutic effects. The objectives of this study were therefore to prepare and characterize transferrin-targeted, PEGylated PLGA nanoparticles entrapping plumbagin, and to evaluate their therapeutic efficacy in vitro and in vivo. The intravenous administration of transferrin-bearing PEGylated PLGA nanoparticles led to the complete suppression of 10% of B16-F10 tumors and regression of 30% of the tumors, with improvement of the animal survival compared to controls. The treatment was well tolerated by the animals. Transferrin-bearing PEGylated PLGA nanoparticles entrapping plumbagin are therefore highly promising therapeutic systems, able to lead to tumor regression and even suppression after intravenous administration without visible toxicity.

Creators(s):	Sakpakdeejaroen, Intouch ORCID: https://orcid.org/0000-0002-5045-7581, Somani, Sukrut ORCID: https://orcid.org/0000-0002-0697-1110, Laskar, Partha, Irving, Craig, Mullin, Margaret and Dufes, Christine ORCID: https://orcid.org/0000-0002-7963-6364;
Item type:	Article
ID code:	69208
Keywords:	Plumbagin, transferrin, tumor targeting, PEGylated OLGA nanoparticles, cancer treatment, Pharmacy and materia medica, Pharmacology, Toxicology and Pharmaceutics(all)
Subjects:	Medicine > Pharmacy and materia medica
Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Technology and Innovation Centre > Bionanotechnology Faculty of Science > Pure and Applied Chemistry
Depositing user:	Pure Administrator
Date deposited:	02 Aug 2019 15:31
Last modified:	25 Jul 2020 02:17
Related URLs:	Journal or Publication
URI:	https://strathprints.strath.ac.uk/id/eprint/69208
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