Development of transferrin-bearing vesicles encapsulating aspirin for cancer therapy

Sakpakdeejaroen, Intouch and Somani, Sukrut and Mullin, Margaret and Dufès, Christine (2019) Development of transferrin-bearing vesicles encapsulating aspirin for cancer therapy. Journal of Liposome Research. ISSN 0898-2104 (In Press)

[img]
Preview
 Text (Sakpakdeejaroen-etal-JLR-2019-Development-of-transferrin-bearing-vesicles-encapsulating-aspirin-for-cancer-therapy)
Sakpakdeejaroen_etal_JLR_2019_Development_of_transferrin_bearing_vesicles_encapsulating_aspirin_for_cancer_therapy.pdf
Accepted Author Manuscript
Download (578kB)| Preview

    Abstract

    Originally developed for the treatment of inflammatory disorders, the non-steroidal antiinflammatory drug aspirin was shown to have a preventive effect against cancer in the past decades. Most importantly, recent studies suggested that it might also provide a therapeutic benefit in the treatment of cancer in vitro. However, this drug failed to specifically reach tumors at a therapeutic concentration following intravenous administration, thus resulting in lack of efficacy on tumors. In this work, we demonstrated that aspirin could be formulated in transferrin-bearing vesicles and that this tumor-targeted formulation could lead to an increase in the anti-proliferative efficacy of the drug in three cancer cell lines in vitro. The in vitro therapeutic efficacy of aspirin was significantly improved when formulated in transferrin-bearing vesicles, by about 2-fold compared to that of drug solution. These results are promising and support the optimization of this delivery system to further improve its potential as a therapeutic tool in combination with other anti-cancer therapies.

    Creators(s): Sakpakdeejaroen, Intouch ORCID logoORCID: https://orcid.org/0000-0002-5045-7581, Somani, Sukrut ORCID logoORCID: https://orcid.org/0000-0002-0697-1110, Mullin, Margaret and Dufès, Christine ORCID logoORCID: https://orcid.org/0000-0002-7963-6364;
    Item type:Article
    ID code:67656
    Keywords:aspirin, transferrin, tumor targeting, drug delivery, cancer therapy, Therapeutics. Pharmacology, Neoplasms. Tumors. Oncology (including Cancer), Pharmacology (medical), Oncology
    Subjects:Medicine > Therapeutics. Pharmacology
    Medicine > Internal medicine > Neoplasms. Tumors. Oncology (including Cancer)
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Depositing user: Pure Administrator
    Date deposited:30 Apr 2019 14:16
    Last modified:09 Jul 2020 02:54
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/67656
    Export data:
    CORE (COnnecting REpositories)