A novel microfluidic drug testing platform for studying communication between independent neural networks

MacKerron, Christopher and Robertson, Graham and Bushell, Trevor and Zagnoni, Michele (2016) A novel microfluidic drug testing platform for studying communication between independent neural networks. In: 10th FENS (Federation of European Neuroscience Societies) Forum of Neuroscience 2016, 2016-07-02 - 2016-07-06.

[img]
Preview
Text (MacKerron-etal-FENS-2016-A-novel-microfluidic-drug-testing-platform-for-studying)
MacKerron_etal_FENS_2016_A_novel_microfluidic_drug_testing_platform_for_studying.pdf
Accepted Author Manuscript

Download (215kB)| Preview

    Abstract

    Many in-vitro systems used during pre-clinical trials fail to recreate the biological complexity of the in-vivo neural microenvironment.Taking advantage of recent advances in microfluidic technology, we seek to develop a perfusion based drug discovery platform that is capable of high-throughput pharmacological profiling. This in turn will allow us to better understand how drugs influence the communication between functionally connected neural networks.