Picture of UK Houses of Parliament

Leading national thinking on politics, government & public policy through Open Access research

Strathprints makes available scholarly Open Access content by researchers in the School of Government & Public Policy, based within the Faculty of Humanities & Social Sciences.

Research here is 1st in Scotland for research intensity and spans a wide range of domains. The Department of Politics demonstrates expertise in understanding parties, elections and public opinion, with additional emphases on political economy, institutions and international relations. This international angle is reflected in the European Policies Research Centre (EPRC) which conducts comparative research on public policy. Meanwhile, the Centre for Energy Policy provides independent expertise on energy, working across multidisciplinary groups to shape policy for a low carbon economy.

Explore the Open Access research of the School of Government & Public Policy. Or explore all of Strathclyde's Open Access research...

The impact of channel fill level on internal forces during continuous twin screw wet granulation

Torrecillas, Carlota Mendez and Gorringe, Lee J. and Rajoub, Nazer and Robertson, John and Elkes, Richard G. and Lamprou, Dimitrios A. and Halbert, Gavin W. (2018) The impact of channel fill level on internal forces during continuous twin screw wet granulation. International Journal of Pharmaceutics. pp. 1-43. ISSN 0378-5173

[img] Text (Gorringe-etal-IJOP-2018-The-impact-of-channel-fill-level-on-internal-forces-during)
Gorringe_etal_IJOP_2018_The_impact_of_channel_fill_level_on_internal_forces_during.pdf
Accepted Author Manuscript
Restricted to Repository staff only until 28 December 2019.
License: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 logo

Download (1MB) | Request a copy from the Strathclyde author

    Abstract

    The forces experienced by the particles inside a twin screw granulator (TSG) are one of the most difficult parameters to measure quantitatively. However, it is possible to perform accurately this measurement through the use of dye containing calibrated microencapsulated sensors (CAMES) whose rupture is directly dependant on their experienced shear stress. The current study measures the extent of local stresses in the transformation from powder to granules at different channel fills during TSG processing. Channel fill has shown good potential as a design tool, however, its validity for predicting particle size distributions has yet to be demonstrated in an 11-mm TSG. The results of this study showed that the particles within the twin screw granulator experienced stresses in the range of 350-1000 kPa and this value was not linear with the specific mechanical energy applied by the granulator. It was observed that the majority of these stresses were produced by material transport processes rather than the granulation in itself. In addition it was determined that the torque required by the TSG increases exponentially after a certain channel fill a feature that requires to be considered in order to design safer, predictable and reliable granulation workspaces.