Alkali metal effects in trans-metal-trapping (TMT) : comparing LiTMP with NaTMP in cooperative MTMP/Ga(CH2SiMe3)3 metalation reactions
McLellan, Ross and Uzelac, Marina and Bole, Leonie J. and Gil-Negrete, Jose Maria and Armstrong, David R. and Kennedy, Alan R. and Mulvey, Robert E. and Hevia, Eva (2019) Alkali metal effects in trans-metal-trapping (TMT) : comparing LiTMP with NaTMP in cooperative MTMP/Ga(CH2SiMe3)3 metalation reactions. Synthesis, 51 (05). pp. 1207-1215. ISSN 0039-7881
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Abstract
Stepwise metalation and trapping, so called trans-metal-trapping (TMT), of anisole is studied using LiTMP as base and Ga(CH2SiMe3)3 as trap. The isolated "trapped" intermediate is also assessed in C-C bond forming reactions, highlighting the inherent advantages and remaining challenges of this system. The same base trap mixture is found to metalate N-Me bonds of the diamines TMEDA and PMDETA. Comparative studies replacing LiTMP by NaTMP have found significant alkali metal effects on the extent of both base-trap cocomplexation and onward reactivities of TMT products.
Creators(s): |
McLellan, Ross ![]() ![]() ![]() ![]() ![]() | Item type: | Article |
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ID code: | 66470 |
Keywords: | metalation, gallium trans metal trapping, carbanions, cooperative effects, lithium, sodium, Chemistry, Chemistry(all) |
Subjects: | Science > Chemistry |
Department: | Faculty of Science > Pure and Applied Chemistry |
Depositing user: | Pure Administrator |
Date deposited: | 08 Jan 2019 10:06 |
Last modified: | 21 Jan 2021 10:38 |
Related URLs: | |
URI: | https://strathprints.strath.ac.uk/id/eprint/66470 |
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