Towards establishing a minimal nanoparticle concentration for applications involving surface enhanced spatially offset resonance Raman spectroscopy (SESORRS) in vivo

Nicolson, Fay and Jamieson, Lauren E. and Mabbott, Samuel and Plakas, Konstantinos and Shand, Neil C. and Detty, Michael R. and Graham, Duncan and Faulds, Karen (2018) Towards establishing a minimal nanoparticle concentration for applications involving surface enhanced spatially offset resonance Raman spectroscopy (SESORRS) in vivo. Analyst, 143. pp. 5358-5363. ISSN 0003-2654

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    Abstract

    Resonant chalcogenpyrylium nanotags demonstrate an exceptional surface enhanced Raman scattering (SERS) performance for use in SORS applications. Using surface enhanced spatially offset Raman spectroscopy (SESORS), nanotags modified with a chalcogenpyrylium dye were observed at concentrations as low as 1 pM through 5 mm of tissue. Calculated limits of detection suggest that these SERS nanotags can be detected at 104 fM using surface enhanced spatially offset resonance Raman scattering (SESORRS) demonstrating their potential for in vivo applications.

    Author(s):Nicolson, Fay ORCID logoORCID: https://orcid.org/0000-0001-7154-9613, Jamieson, Lauren E. ORCID logoORCID: https://orcid.org/0000-0002-8996-2964, Mabbott, Samuel ORCID logoORCID: https://orcid.org/0000-0003-4926-5467, Plakas, Konstantinos, Shand, Neil C., Detty, Michael R., Graham, Duncan ORCID logoORCID: https://orcid.org/0000-0002-6079-2105 and Faulds, Karen ORCID logoORCID: https://orcid.org/0000-0002-5567-7399
    Item type:Article
    ID code:66156
    Keywords:Raman, SERS, SORS, SESORS, SERRS, SESORRS, nanoparticle, LOD, Chemistry, Spectroscopy
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Strategic Research Themes > Health and Wellbeing
    Depositing user: Pure Administrator
    Date deposited:19 Nov 2018 12:29
    Last modified:09 Jan 2020 01:25
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/66156
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