Selective meta-deprotonation of toluene by using alkali-metal-mediated magnesiation

Andrikopoulos, Prokopis C. and Armstrong, David R. and Graham, David V. and Hevia, Eva and Kennedy, Alan R. and Mulvey, Robert E. and O'Hara, Charles T. and Talmard, Christine (2005) Selective meta-deprotonation of toluene by using alkali-metal-mediated magnesiation. Angewandte Chemie, 44 (22). pp. 3459-3462. ISSN 0044-8249 (https://doi.org/10.1002/anie.200500379)

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Abstract

Conventional meta-deprotonation of toluene leads to resonance of Benzylanionen. But with a new type of bimetallic metalation, the sodium-mediated Magnesierung, can shift the thermodynamic meta-deprotonation in the ring.

ORCID iDs

Andrikopoulos, Prokopis C., Armstrong, David R., Graham, David V., Hevia, Eva ORCID logoORCID: https://orcid.org/0000-0002-3998-7506, Kennedy, Alan R. ORCID logoORCID: https://orcid.org/0000-0003-3652-6015, Mulvey, Robert E. ORCID logoORCID: https://orcid.org/0000-0002-1015-2564, O'Hara, Charles T. and Talmard, Christine;
  • Item type:Article
    ID code:651
    Dates:
    Date
    Event
    30 May 2005
    Published
    21 April 2005
    Published Online
    Keywords:deprotonation, inverse crown compounds, magnesium, metalation, sodium, Chemistry, Medicine(all)
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Mr Derek Boyle
    Date deposited:28 Mar 2006
    Last modified:30 Mar 2023 01:11
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/651
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