Targeted nonviral gene therapy in prostate cancer
Altwaijry, Najla and Somani, Sukrut and Dufès, Christine (2018) Targeted nonviral gene therapy in prostate cancer. International Journal of Nanomedicine, 13. 5753—5767. ISSN 1176-9114 (https://doi.org/10.2147/IJN.S139080)
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Abstract
Prostate cancer is the second most widespread cancer in men worldwide. Treatment choices are limited to prostatectomy, hormonal and radiotherapy that commonly have deleterious side effects and vary in their efficacy, depending on the stage of the disease. Among novel experimental strategies, gene therapy holds great promise for the treatment of prostate cancer. However, its use is currently limited by the lack of delivery systems able to selectively deliver the therapeutic genes to the tumors after intravenous administration without major drawbacks. To remediate to this problem, a wide range of non-viral delivery approaches have been developed to specifically deliver DNA-based therapeutic agents to their site of action. This review provides an overview of the various non-viral delivery strategies and gene therapy concepts used to deliver therapeutic DNA to prostate cancer cells, and focuses on the recent therapeutic advances being made so far.
ORCID iDs
Altwaijry, Najla ORCID: https://orcid.org/0000-0002-1203-9522, Somani, Sukrut ORCID: https://orcid.org/0000-0002-0697-1110 and Dufès, Christine ORCID: https://orcid.org/0000-0002-7963-6364;-
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Item type: Article ID code: 64396 Dates: DateEvent25 September 2018Published8 June 2018AcceptedSubjects: Medicine > Internal medicine > Neoplasms. Tumors. Oncology (including Cancer) Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Technology and Innovation Centre > BionanotechnologyDepositing user: Pure Administrator Date deposited: 11 Jun 2018 11:31 Last modified: 11 Nov 2024 12:01 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/64396