Hospital usage of TOXBASE in Great Britain : temporal trends in accesses 2008 to 2015

Pyper, K and Eddleston, M and Bateman, DN and Lupton, D and Bradberry, S and Sandilands, E and Thomas, SHL and Thompson, JP and Robertson, C (2018) Hospital usage of TOXBASE in Great Britain : temporal trends in accesses 2008 to 2015. Human and Experimental Toxicology, 37 (11). pp. 1207-1214. ISSN 0960-3271 (https://doi.org/10.1177/0960327118759405)

[thumbnail of Pyper-etal-HET-2018-Hospital-usage-of-TOXBASE-in-Great-Britain-temporal-trends]
Preview
 Text. Filename: Pyper_etal_HET_2018_Hospital_usage_of_TOXBASE_in_Great_Britain_temporal_trends.pdf
Accepted Author Manuscript
Download (359kB)| Preview

Abstract

Aim: Examining temporal trends in accesses to the UK's National Poison Information Service's TOXBASE database in Britain. Methods: Generalised additive models were used to examine trends in daily numbers of accesses to TOXBASE from British emergency departments between January 2008 and December 2015. Day-of-the-week, seasonality and long term trends were analysed at national and regional levels (Wales, Scotland and the 9 English Government Office Regions). Results: The long-term trend in daily accesses increases from 2.8 (95% CI:2.6, 3.0) per user on 1st January 2008 to 4.6 (95% CI:4.3, 4.9) on 31st December 2015, with small but significant differences in population-corrected accesses by region (p<0.001). There are statistically significant seasonal and day of the week patterns (p<0.001) across all regions. Accesses are 18 % (95% CI:14%, 22%) higher in summer than in January and at the weekend compared to weekdays in all regions; there is a 7.5% (95% CI:6.1%, 8.9%) increase between Friday and Sunday. Conclusions: There are consistent in-year patterns in access to TOXBASE indicating potential seasonal patterns in poisonings in Britain, with location-dependant rates of usage. This novel descriptive work lays the basis for future work on the interaction of TOXBASE use with emergency admission of patients into hospital.

ORCID iDs

Pyper, K ORCID logoORCID: https://orcid.org/0000-0002-7782-1048, Eddleston, M, Bateman, DN, Lupton, D, Bradberry, S, Sandilands, E, Thomas, SHL, Thompson, JP and Robertson, C;
  • Item type:Article
    ID code:63490
    Dates:
    Date
    Event
    1 November 2018
    Published
    20 February 2018
    Published Online
    26 December 2017
    Accepted
    8 December 2017
    Submitted
    Keywords:poisons information, epidemiology, time trends, regional variation, seasonality, Therapeutics. Pharmacology, Health, Toxicology and Mutagenesis, Toxicology
    Subjects:Medicine > Therapeutics. Pharmacology
    Department:Faculty of Science > Mathematics and Statistics
    Depositing user: Pure Administrator
    Date deposited:15 Mar 2018 12:44
    Last modified:27 Nov 2022 03:35
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/63490
CORE (COnnecting REpositories)