Cooperative, ion-sensitive co-assembly of tripeptide hydrogels

Abul-Haija, Yousef M. and Scott, Gary G. and Sahoo, Jugal Kishore and Tuttle, Tell and Ulijn, Rein V. (2017) Cooperative, ion-sensitive co-assembly of tripeptide hydrogels. Chemical Communications. pp. 9562-9565. ISSN 1359-7345

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    Abstract

    Peptide co-assembly is of interest for the development of functional supramolecular biomaterials. Herein, computational simulations were combined with experimental validation to aid the design and understanding of cooporative co-assembly of a structure-forming tripeptide (FFD) and a functional copper-binding tripeptide (GHK) leading to hydrogel formation in response to complexation with copper ions.