Applications of hydrogen isotopes in the life sciences

Atzrodt, Jens and Derdau, Volker and Kerr, William J. and Reid, Marc (2017) Applications of hydrogen isotopes in the life sciences. Angewandte Chemie International Edition. pp. 1-26. ISSN 1433-7851

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    Abstract

    Hydrogen isotopes are unique tools for identifying and understanding biological or chemical processes. Hydrogen isotope labeling allows for a traceless and direct incorporation of an additional mass or radioactive tag into an organic molecule with almost no change in its chemical structure, physical properties or biological activity. Using deuterium labeled isotopologues to study the unique mass spectrometric (MS)-pattern generated from mixtures of biological relevant molecules drastically simplifies analysis. Such methods are now providing unprecedented levels of insight in a wide and continuously growing range of applications in the life sciences and beyond. Tritium (3H), in particular, has seen an increased utilization, especially in pharmaceutical drug discovery. The efforts and costs required for the synthesis of labeled compounds are more than compensated for by the enhanced molecular sensitivity for analysis and high reliability of the data obtained. In this review, advances in the applications of hydrogen isotopes in the life sciences are described.

    ORCID iDs

    Atzrodt, Jens, Derdau, Volker, Kerr, William J. ORCID logoORCID: https://orcid.org/0000-0002-1332-785X and Reid, Marc ORCID logoORCID: https://orcid.org/0000-0003-4394-3132;
    • Item type:Article
      ID code:61614
      Dates:
      Date
      Event
      16 August 2017
      Published
      16 August 2017
      Published Online
      15 August 2017
      Accepted
      Notes:This is the peer reviewed version of the following article: Atzrodt, J, Derdau, V, Kerr, WJ & Reid, M 2017, 'Applications of hydrogen isotopes in the life sciences' Angewandte Chemie International Edition, pp. 1-26, which has been published in final form at https://doi.org/10.1002/anie.201704146. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
      Keywords:hydrogen isotopes, drug discovery, Chemistry, Chemistry(all)
      Subjects:Science > Chemistry
      Department:Faculty of Science > Pure and Applied Chemistry
      Depositing user: Pure Administrator
      Date deposited:21 Aug 2017 14:34
      Last modified:11 Jun 2021 02:40
      Related URLs:
      URI:https://strathprints.strath.ac.uk/id/eprint/61614
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