Deuterium‐and tritium‐labelled compounds : applications in the life sciences

Atzrodt, Jens and Derdau, Volker and Kerr, William and Reid, Marc (2018) Deuterium‐and tritium‐labelled compounds : applications in the life sciences. Angewandte Chemie International Edition, 57 (7). pp. 1758-1784. ISSN 1521-3773 (https://doi.org/10.1002/anie.201704146)

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Abstract

Hydrogen isotopes are unique tools for identifying and understanding biological and chemical processes. Hydrogen isotope labelling allows for the traceless and direct incorporation of an additional mass or radioactive tag into an organic molecule with almost no changes in its chemical structure, physical properties, or biological activity. Using deuterium-labelled isotopologues to study the unique mass-spectrometric patterns generated from mixtures of biologically relevant molecules drastically simplifies analysis. Such methods are now providing unprecedented levels of insight in a wide and continuously growing range of applications in the life sciences and beyond. Tritium (3H), in particular, has seen an increase in utilization, especially in pharmaceutical drug discovery. The efforts and costs associated with the synthesis of labelled compounds are more than compensated for by the enhanced molecular sensitivity during analysis and the high reliability of the data obtained. In this Review, advances in the application of hydrogen isotopes in the life sciences are described.

ORCID iDs

Atzrodt, Jens, Derdau, Volker, Kerr, William ORCID logoORCID: https://orcid.org/0000-0002-1332-785X and Reid, Marc ORCID logoORCID: https://orcid.org/0000-0003-4394-3132;
  • Item type:Article
    ID code:61614
    Dates:
    Date
    Event
    12 February 2018
    Published
    16 August 2017
    Published Online
    15 August 2017
    Accepted
    Notes:This is the peer reviewed version of the following article: Atzrodt, J, Derdau, V, Kerr, WJ & Reid, M 2017, 'Applications of hydrogen isotopes in the life sciences' Angewandte Chemie International Edition, pp. 1-26, which has been published in final form at https://doi.org/10.1002/anie.201704146. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:21 Aug 2017 14:34
    Last modified:03 Dec 2024 06:21
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/61614
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