Polymeric peptide pigments with sequence-encoded properties

Lampel, Ayala and McPhee, Scott A. and Park, Hang-Ah and Scott, Gary G. and Humagain, Sunita and Hekstra, Doeke R. and Yoo, Barney and Frederix, Pim W. J. M. and Li, Tai-De and Abzalimov, Rinat R. and Greenbaum, Steven G. and Tuttle, Tell and Hu, Chunhua and Bettinger, Christopher J. and Ulijn, Rein V. (2017) Polymeric peptide pigments with sequence-encoded properties. Science, 356 (6342). pp. 1064-1068. ISSN 1095-9203

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    Abstract

    Melanins are a family of heterogeneous polymeric pigments that provide ultraviolet (UV) light protection, structural support, coloration, and free radical scavenging. Formed by oxidative oligomerization of catecholic small molecules, the physical properties of melanins are influenced by covalent and noncovalent disorder. We report the use of tyrosine-containing tripeptides as tunable precursors for polymeric pigments. In these structures, phenols are presented in a (supra-)molecular context dictated by the positions of the amino acids in the peptide sequence. Oxidative polymerization can be tuned in a sequence-dependent manner, resulting in peptide sequence–encoded properties such as UV absorbance, morphology, coloration, and electrochemical properties over a considerable range. Short peptides have low barriers to application and can be easily scaled, suggesting near-term applications in cosmetics and biomedicine.

    ORCID iDs

    Lampel, Ayala, McPhee, Scott A., Park, Hang-Ah, Scott, Gary G. ORCID logoORCID: https://orcid.org/0000-0003-2177-0373, Humagain, Sunita, Hekstra, Doeke R., Yoo, Barney, Frederix, Pim W. J. M., Li, Tai-De, Abzalimov, Rinat R., Greenbaum, Steven G., Tuttle, Tell, Hu, Chunhua, Bettinger, Christopher J. and Ulijn, Rein V. ORCID logoORCID: https://orcid.org/0000-0001-7974-3779;
    • Item type:Article
      ID code:60910
      Dates:
      Date
      Event
      9 June 2017
      Published
      9 June 2017
      Published Online
      8 May 2017
      Accepted
      Notes:This is the author's version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science on 09 June 2017 in volume 356, DOI: 10.1126/science.aal5005.
      Keywords:ultraviolet light protection, UV, melanins, polymeric peptide pigments, Physical and theoretical chemistry, Chemistry(all)
      Subjects:Science > Chemistry > Physical and theoretical chemistry
      Department:Faculty of Science > Pure and Applied Chemistry
      Technology and Innovation Centre > Bionanotechnology
      Depositing user: Pure Administrator
      Date deposited:12 Jun 2017 14:53
      Last modified:19 Jan 2022 01:41
      Related URLs:
      URI:https://strathprints.strath.ac.uk/id/eprint/60910
    CORE (COnnecting REpositories)