Iridium-catalyzed formyl-selective deuteration of aldehydes
Kerr, William John and Reid, Marc and Tuttle, Tell (2017) Iridium-catalyzed formyl-selective deuteration of aldehydes. Angewandte Chemie International Edition, 56 (27). 7808–7812. ISSN 1433-7851
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Official URL: https://doi.org/10.1002/anie.201702997
Abstract
We report the first direct catalytic method for formyl-selective deuterium labeling of aromatic aldehydes under mild conditions, using an iridium-based catalyst designed to favor formyl- over aromatic C-H activation. A good range of aromatic aldehydes is selectively labeled, and a one-pot labeling/olefination protocol is also described. Computational studies support kinetic product control over competing aromatic labeling and decarbonylation pathways.
Author(s): | Kerr, William John ![]() ![]() | Item type: | Article |
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ID code: | 60711 |
Keywords: | C-H activation, aldehyde, iridium catalysis, Chemistry, Organic Chemistry, Inorganic Chemistry, Physical and Theoretical Chemistry |
Subjects: | Science > Chemistry |
Department: | Faculty of Science > Pure and Applied Chemistry Technology and Innovation Centre > Bionanotechnology |
Depositing user: | Pure Administrator |
Date deposited: | 18 May 2017 10:30 |
Last modified: | 06 Dec 2019 05:09 |
Related URLs: | |
URI: | https://strathprints.strath.ac.uk/id/eprint/60711 |
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