Iridium-catalyzed formyl-selective deuteration of aldehydes

Kerr, William John and Reid, Marc and Tuttle, Tell (2017) Iridium-catalyzed formyl-selective deuteration of aldehydes. Angewandte Chemie International Edition, 56 (27). 7808–7812. ISSN 1433-7851

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    Abstract

    We report the first direct catalytic method for formyl-selective deuterium labeling of aromatic aldehydes under mild conditions, using an iridium-based catalyst designed to favor formyl- over aromatic C-H activation. A good range of aromatic aldehydes is selectively labeled, and a one-pot labeling/olefination protocol is also described. Computational studies support kinetic product control over competing aromatic labeling and decarbonylation pathways.

    Author(s):Kerr, William John ORCID logoORCID: https://orcid.org/0000-0002-1332-785X, Reid, Marc ORCID logoORCID: https://orcid.org/0000-0003-4394-3132 and Tuttle, Tell
    Item type:Article
    ID code:60711
    Keywords:C-H activation, aldehyde, iridium catalysis, Chemistry, Organic Chemistry, Inorganic Chemistry, Physical and Theoretical Chemistry
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Technology and Innovation Centre > Bionanotechnology
    Depositing user: Pure Administrator
    Date deposited:18 May 2017 10:30
    Last modified:06 Dec 2019 05:09
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/60711
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