Iridium-catalyzed formyl-selective deuteration of aldehydes
Kerr, William J. and Reid, Marc and Tuttle, Tell (2017) Iridium-catalyzed formyl-selective deuteration of aldehydes. Angewandte Chemie International Edition, 56 (27). 7808–7812. ISSN 1433-7851
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Official URL: https://doi.org/10.1002/anie.201702997
Abstract
We report the first direct catalytic method for formyl-selective deuterium labeling of aromatic aldehydes under mild conditions, using an iridium-based catalyst designed to favor formyl- over aromatic C-H activation. A good range of aromatic aldehydes is selectively labeled, and a one-pot labeling/olefination protocol is also described. Computational studies support kinetic product control over competing aromatic labeling and decarbonylation pathways.
ORCID iDs
Kerr, William J.
ORCID: https://orcid.org/0000-0002-1332-785X, Reid, Marc ORCID: https://orcid.org/0000-0003-4394-3132 and Tuttle, Tell;
Item type: Article ID code: 60711 Dates: DateEvent26 June 2017Published16 May 2017Published Online16 May 2017AcceptedKeywords: C-H activation, aldehyde, iridium catalysis, Chemistry, Organic Chemistry, Inorganic Chemistry, Physical and Theoretical Chemistry Subjects: Science > Chemistry Department: Faculty of Science > Pure and Applied Chemistry
Technology and Innovation Centre > BionanotechnologyDepositing user: Pure Administrator Date deposited: 18 May 2017 10:30 Last modified: 13 Jun 2021 00:44 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/60711
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CORE (COnnecting REpositories)