Perfusion based microfluidic system for pharmacological profiling of neuronal networks

MacKerron, C. and Robertson, G. and Bushell, T.J. and Zagnoni, M.; (2016) Perfusion based microfluidic system for pharmacological profiling of neuronal networks. In: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). Chemical and Biological Microsystems Society, IRL, pp. 445-446. ISBN 9781510834163

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Abstract

This work presents the integration of a semi-automated microfluidic platform that utilizes calcium imaging to enable the pharmacological characterization of functionally connected, but environmentally isolated neuronal networks. This approach allows, for the first time, to assess the cause-effect relationship of neuronal communication following drug application, thus allowing the pharmacological characterisation of novel drugs proposed to influence communication between neuronal networks.

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• Item metadata

  Item type:	Book Section
  ID code:	60310
  Dates:	Date Event 9 October 2016 Published 24 June 2016 Accepted
  Subjects:	Technology > Engineering (General). Civil engineering (General) > Bioengineering
  Department:	Faculty of Engineering > Electronic and Electrical Engineering Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
  Depositing user:	Pure Administrator
  Date deposited:	27 Mar 2017 11:51
  Last modified:	08 Apr 2024 13:38
  Related URLs:	Organisation Event
  URI:	https://strathprints.strath.ac.uk/id/eprint/60310