Activated carbon as a carrier for amorphous drug delivery : effect of drug characteristics and carrier wettability

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Miriyala, Nikhila and Ouyang, Defang and Perrie, Yvonne and Lowry, Deborah and Kirby, Daniel J. (2017) Activated carbon as a carrier for amorphous drug delivery : effect of drug characteristics and carrier wettability. European Journal of Pharmaceutics and Biopharmaceutics, 115. pp. 197-205. ISSN 0939-6411 (https://doi.org/10.1016/j.ejpb.2017.03.002)

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Abstract

Recent research on porous silica materials as drug carriers for amorphous and controlled drug delivery has shown promising results. However, due to contradictory literature reports on toxicity and high costs of production, it is important to explore alternative safe and inexpensive porous carriers. In this study, the potential of activated carbon (AC) as an amorphous drug carrier was investigated using paracetamol (PA) and ibuprofen (IBU) as model drugs. The solution impregnation method was used for drug loading, with loading efficiency determined by UV spectroscopy and drug release kinetics studied using USP II dissolution apparatus. The physical state of the drug in the complex was characterised using differential scanning calorimetry and X-ray diffractions techniques, whilst sites of drug adsorption were studied using Fourier transform infrared spectroscopy and N2 adsorption techniques. In addition, the cytotoxicity of AC on human colon carcinoma (Caco-2) cells was assessed using the MTT assay. Results presented here reveal that, for PA/AC and IBU/AC complexes, the saturation solubility of the drug in the loading solvent appears to have an effect on the drug loading efficiency and the physical state of the drug loaded, whilst drug release kinetics were affected by the wettability of the activated carbon particles. Furthermore, activated carbon microparticles exhibited very low cytotoxicity on Caco-2 cells at the concentrations tested (10-800 µg/mL). This study, therefore, supports the potential of activated carbon as a carrier for amorphous drug delivery.

  • Item type:Article
    ID code:60099
    Dates:
    Date
    Event
    1 June 2017
    Published
    8 March 2017
    Published Online
    6 March 2017
    Accepted
    3 February 2017
    Submitted
    Notes:© 2017 Elsevier B.V. All rights reserved. Nikhila Miriyala, Defang Ouyang, Yvonne Perrie, Deborah Lowry, Daniel J. Kirby, Activated carbon as a carrier for amorphous drug delivery: Effect of drug characteristics and carrier wettability, European Journal of Pharmaceutics and Biopharmaceutics, Volume 115, 2017, Pages 197-205, https://doi.org/10.1016/j.ejpb.2017.03.002
    Subjects:Medicine > Pharmacy and materia medica
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Depositing user: Pure Administrator
    Date deposited:08 Mar 2017 09:51
    Last modified:03 Dec 2024 23:49
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/60099
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