Manufacturing methods for liposome adjuvants

Perrie, Yvonne and Kastner, Elisabeth and Khadke, Swapnil and Roces, Carla B. and Stone, Peter (2016) Manufacturing methods for liposome adjuvants. In: Vaccine Adjuvants. Methods in Molecular Biology . Springer New York, New York, pp. 127-144. ISBN 978-1-4939-6443-7

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Abstract

A wide range of studies have shown that liposomes can act as suitable adjuvants for a range of vaccine antigens. Properties such as their amphiphilic character and biphasic nature allow them to incorporate antigens within the lipid bilayer, on the surface, or encapsulated within the inner core. However, appropriate methods for the manufacture of liposomes are limited and this has resulted in issues with cost, supply, and wider scale application of these systems. Within this chapter we explore manufacturing processes that can be used for the production of liposomal adjuvants, and we outline new manufacturing methods can that offer fast, scalable, and cost-effective production of liposomal adjuvants.