Parasite excretory-secretory products and their effects on metabolic syndrome

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Crowe, Jenny and Lumb, Felicity E. and Harnett, Margaret M. and Harnett, William (2017) Parasite excretory-secretory products and their effects on metabolic syndrome. Parasite Immunology. ISSN 0141-9838 (https://doi.org/10.1111/pim.12410)

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Abstract

Obesity, one of the main causes of metabolic syndrome (MetS), is an increasingly common health and economic problem worldwide, and one of the major risk factors for developing type 2 diabetes and cardiovascular disease. Chronic, low-grade inflammation is associated with MetS and obesity. A dominant type 2/anti-inflammatory response is required for metabolic homeostasis within adipose tissue: during obesity, this response is replaced by infiltrating, inflammatory macrophages and T cells. Helminths and certain protozoan parasites are able to manipulate the host immune response towards a TH2 immune phenotype that is beneficial for their survival and there is emerging data that there is an inverse correlation between the incidence of MetS and helminth infections, suggesting that, as with autoimmune and allergic diseases, helminths may play a protective role against MetS disease. Within this review, we will focus primarily on the excretory-secretory products that the parasites produce to modulate the immune system and discuss their potential use as therapeutics against MetS and its associated pathologies.

ORCID iDs

Crowe, Jenny, Lumb, Felicity E. ORCID logoORCID: https://orcid.org/0000-0001-9742-5125, Harnett, Margaret M. and Harnett, William ORCID logoORCID: https://orcid.org/0000-0001-9545-9401;
  • Item type:Article
    ID code:59341
    Dates:
    Date
    Event
    9 January 2017
    Published
    9 January 2017
    Published Online
    5 January 2017
    Accepted
    Notes:This is the peer reviewed version of the following article: Crowe, J., Lumb, F. E., Harnett, M. M., & Harnett, W. (2017). Parasite excretory-secretory products and their effects on metabolic syndrome. Parasite Immunology, which has been published in final form at https://dx.doi.org/10.1111/pim.12410. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving
    Subjects:Science > Microbiology > Immunology
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Depositing user: Pure Administrator
    Date deposited:10 Jan 2017 09:37
    Last modified:12 Dec 2024 04:59
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/59341
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