A microfluidics tool for high-throughput, real-time multimodal imaging of nanoparticle-cell interactions
Cunha-Matos, C. A. and Millington, O. M. and Wark, A. W. and Zagnoni, M.; Colin, Stéphane and Morini, Gian Luca and Brandner, Jürgen J., eds. (2014) A microfluidics tool for high-throughput, real-time multimodal imaging of nanoparticle-cell interactions. In: 4th European Conference on Microfluidics, Limerick, 10-12 December 2014. Société hydrotechnique de France, IRL. ISBN 9791093567044
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Abstract
The increasing use of nanomaterials for biomedical applications has raised the need for efficient, robust and low-cost high-throughput assessment of nanotoxicity and cell-nanoparticle interactions. Microfluidics provides the tools for high-throughput single-cell functional monitoring, while gold nanorods have unique potential for intracellular tracking and can simultaneously be used as drug carriers. Presented here is a miniaturised platform that integrates these features with a multimodal approach to cell imaging. A microfluidic device allows for trapping of an array of singlecells, followed by the controlled delivery of nanoparticles into the cell array and subsequent real-time multimodal imaging of cellular interactions with functionalised nanoparticles. This system has been successfully used to assess cellnanoparticle interactions at the single-cell level.
ORCID iDs
Cunha-Matos, C. A. ORCID: https://orcid.org/0000-0001-5528-1725, Millington, O. M. ORCID: https://orcid.org/0000-0002-3026-6550, Wark, A. W. ORCID: https://orcid.org/0000-0001-8736-7566 and Zagnoni, M. ORCID: https://orcid.org/0000-0003-3198-9491; Colin, Stéphane, Morini, Gian Luca and Brandner, Jürgen J.-
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Item type: Book Section ID code: 58066 Dates: DateEventDecember 2014Published10 September 2014AcceptedSubjects: Technology > Engineering (General). Civil engineering (General) > Bioengineering Department: Faculty of Engineering > Biomedical Engineering
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Science > Pure and Applied Chemistry
Technology and Innovation Centre > Bionanotechnology
Faculty of Engineering > Electronic and Electrical EngineeringDepositing user: Pure Administrator Date deposited: 05 Oct 2016 09:34 Last modified: 04 Oct 2024 00:10 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/58066