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Open Access research with a European policy impact...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the European Policies Research Centre (EPRC).

EPRC is a leading institute in Europe for comparative research on public policy, with a particular focus on regional development policies. Spanning 30 European countries, EPRC research programmes have a strong emphasis on applied research and knowledge exchange, including the provision of policy advice to EU institutions and national and sub-national government authorities throughout Europe.

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Effect of home-based strength training program on Igf-i, Igfbp-1 and Igfbp-3 in obese Latino boys participating in a 16 week randomized controlled trial : 2425 Board #6 June 3, 9:30 AM - 11:30 AM

Kelly, Louise A. and Todd Schroeder, E. and Loza, Armando and Lin, Xiao and Moody, Alastair E. and Hughes, Adrienne and Kirk, Alison and Knowles, Ann-Marie (2016) Effect of home-based strength training program on Igf-i, Igfbp-1 and Igfbp-3 in obese Latino boys participating in a 16 week randomized controlled trial : 2425 Board #6 June 3, 9:30 AM - 11:30 AM. Medicine and Science in Sports and Exercise, 48 (5S). p. 665. ISSN 0195-9131

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Abstract

BACKGROUND: Accumulating evidence indicates circulating concentrations of insulin-like growth factor 1 (IGF-1), or IGF-1 relative to IGF binding proteins (IGFBP’s) is associated with increased risk for the development of several forms of cancers. Similarly, exercise has been linked with reduced cancer risk. PURPOSE: To assess the effects of a 16-week (2xweek) home-based strength training (HBST) program on serum IGF-1, IGFBP-1, IGFBP3, and their ratio we randomized 32 obese Latino adolescent males (aged 14-18 years) into a twice-weekly Home Based Strength Training group (HBST;n=16) or a Control group (C;n=16) for 16 weeks. METHODS: Home-based strength training for 16 weeks, composed of two one-hour sessions per week. Outcome Measures were assessed pre- and post intervention/control condition and included IGF-1, IGFBP-1 and IGFBP-3, fasting glucose, two-hour glucose, Body Mass Index (BMI), dual energy X-ray absorptiometry (DEXA) scan, dietary intake and physical activity using the Actigraph GT1X. GLM was used to assess differences in changes in outcome measures, between the C and the HBST groups. RESULTS: Over the 16 weeks of the intervention there was a trend for a significant within-subject’s differences for IGF 1 (p=0.078), but no significant within-subject’s differences for IGFBP-1 (p=0.187), IGFBP-3 (p=0.490), fasting glucose (p=0.87), and 2-hr glucose (p=0.38). There were also no between subject differences noted in fasting glucose (p=0.36), 2-hr glucose (p=0.84), SI (p=0.34), AIR (p=0.27), and DI (p=0.73). There was a trend for a between subject differences in IGF1 (p = 0.081). There were also no between subject differences noted in IGFBP-1 (p=0.194), IGFBP-3 (p = 0.202), fasting glucose (p=0.36), and 2-hr glucose (p=0.84). CONCLUSIONS: These preliminary results suggest that a twice per week 16-week home based strength training program does not affect concentrations of IGF-1, IGFBP-1, and IGFBP-3, in obese Latino boys.