Therapeutic drug monitoring in the past 40 years of the JAC

Reeves, David and Lovering, Andrew and Thomson, Alison (2016) Therapeutic drug monitoring in the past 40 years of the JAC. Journal of Antimicrobial Chemotherapy, 71 (12). pp. 3330-3332. ISSN 0305-7453 (

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Since the Journal was first published in 1975, papers addressing therapeutic drug monitoring (TDM) have been a regular feature. Initially they focused on laboratory aspects of drug concentration measurement then they changed more to the application of TDM in a clinical setting. Over its history, the Journal has provided its readership with the latest technological and scientific advances in TDM and has helped to drive changes in TDM that have directly impacted on patient care. These have varied from improvement in the quality of antimicrobial measurements through better identification of dosage regimens and TDM targets that help predict outcome and adverse events.