Reflux precipitation polymerization : a new synthetic insight in molecular imprinting at high temperature

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Shen, Xiantao and Huang, Chuixiu and Shinde, Sudhirkumar and Switnicka-Plak, Magdalena and Cormack, Peter and Sellergren, Börje (2016) Reflux precipitation polymerization : a new synthetic insight in molecular imprinting at high temperature. RSC Advances, 6 (85). pp. 81491-81499. ISSN 2046-2069 (https://doi.org/10.1039/C6RA15990G)

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Abstract

Synthesis of uniform molecularly imprinted polymer (MIP) microspheres (MSs) using distillation precipitation polymerization (DPP) at high temperature has attracted great interest in the field of molecular imprinting. However,there were still some shortcomings in this method. In this work, to create uniform MIP MSs in a short time and to demonstrate the effects of high temperature on imprinting performance, a new precipitation polymerization method (reflux precipitation polymerization, RPP) was used for the first time to fabricate MIP MSs in this study. The SEM images of the polymeric MSs indicate the presence of template molecules could improve the particle morphology and size uniformity. The specific molecular recognition of the monodispersed MIP MSs was confirmed by fluorescence measurement and HPLC-UV analysis. The binding behavior of the MIP MSs was simulated using the heterogeneous Freundlich isotherm, which shows that the MIP MSs produced by the RPP possess compatible selectivity in comparison with those by traditional PP method. It is noted that, for the first time, we demonstrated that molecular imprinting at high temperature was only successful when electrostatic interactions played important roles in the imprinting process.

ORCID iDs

Shen, Xiantao, Huang, Chuixiu, Shinde, Sudhirkumar, Switnicka-Plak, Magdalena ORCID logoORCID: https://orcid.org/0000-0003-2048-0745, Cormack, Peter ORCID logoORCID: https://orcid.org/0000-0002-3390-8176 and Sellergren, Börje;
  • Item type:Article
    ID code:57515
    Dates:
    Date
    Event
    22 August 2016
    Published
    22 August 2016
    Published Online
    20 August 2016
    Accepted
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:23 Aug 2016 13:25
    Last modified:14 Nov 2024 01:09
    URI:https://strathprints.strath.ac.uk/id/eprint/57515
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