MMP-9 triggered self-assembly of doxorubicin nanofiber depots halts tumor growth
Kalafatovic, Daniela and Nobis, Max and Son, Jiye and Anderson, Kurt I. and Ulijn, Rein V. (2016) MMP-9 triggered self-assembly of doxorubicin nanofiber depots halts tumor growth. Biomaterials, 98. pp. 192-202. ISSN 1878-5905 (https://doi.org/10.1016/j.biomaterials.2016.04.039)
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Abstract
A central challenge in cancer care is to ensure that therapeutic compounds reach their targets. One approach is to use enzyme-responsive biomaterials, which reconfigure in response to endogenous enzymes that are overexpressed in diseased tissues, as potential site-specific anti-tumoral therapies. Here we report peptide micelles that upon MMP-9 catalyzed hydrolysis reconfigure to form fibrillar nanostructures. These structures slowly release a doxorubicin payload at the site of action. Using both in vitro and in vivo models we demonstrate that the fibrillar depots are formed at the sites of MMP-9 overexpression giving rise to enhanced efficacy of doxorubicin, resulting in inhibition of tumor growth in an animal model.
ORCID iDs
Kalafatovic, Daniela, Nobis, Max, Son, Jiye, Anderson, Kurt I. and Ulijn, Rein V. ORCID: https://orcid.org/0000-0001-7974-3779;-
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Item type: Article ID code: 57064 Dates: DateEvent31 August 2016Published30 April 2016Published Online28 April 2016AcceptedSubjects: Science > Chemistry Department: Faculty of Science > Pure and Applied Chemistry
Technology and Innovation Centre > BionanotechnologyDepositing user: Pure Administrator Date deposited: 25 Jul 2016 08:37 Last modified: 03 Nov 2024 01:55 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/57064