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Open Access research with a European policy impact...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the European Policies Research Centre (EPRC).

EPRC is a leading institute in Europe for comparative research on public policy, with a particular focus on regional development policies. Spanning 30 European countries, EPRC research programmes have a strong emphasis on applied research and knowledge exchange, including the provision of policy advice to EU institutions and national and sub-national government authorities throughout Europe.

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Integrated time sampling design and measurement set selection for biochemical systems

Yu, Hui and Yu, Hening and Yue, Hong and Zhou, Jinglin (2016) Integrated time sampling design and measurement set selection for biochemical systems. In: 2016 22nd International Conference on Automation and Computing (ICAC). IEEE, pp. 1-6. ISBN 978-1-86218-132-8

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Abstract

The optimal experimental design (OED) for observation strategy is investigated in this paper to collect the most informative experimental data for parameter estimation. The aim is to determine the best sampling time points and also select the most valuable measurement state variables through OED. The two design objectives are integrated together as a single-objective optimisation problem in which the variables and their sampling times are weighted in an expanded time sampling framework. Three optimisation methods, i.e., the Powell’s method, the sequen- tial selection method, and the sequential quadratic programming method, are employed to solve the optimisation problem. Their computation efficiencies are compared using a biodiesel case study system simulation. Simulation results demonstrate the effectiveness of the proposed method in reducing parameter estimation uncertainties as well as reducing parameter correlations. It can also be observed that the integrated OED doesn’t cost extra computation efforts when variable selection is considered together with the time sampling task.