Solvates, salts, and cocrystals : a proposal for a feasible classification system

Grothe, E. and Meekes, H. and Vlieg, E. and Ter Horst, J. H. and De Gelder, R. (2016) Solvates, salts, and cocrystals : a proposal for a feasible classification system. Crystal Growth and Design, 16 (6). pp. 3237-3243. ISSN 1528-7483 (https://doi.org/10.1021/acs.cgd.6b00200)

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Abstract

The design of pharmaceutical cocrystals has initiated widespread debate on the classification of cocrystals. Current attempts to classify multicomponent crystals suffer from ambiguity, which has led to inconsistent definitions for cocrystals and for multicomponent crystals in general. Inspired by the work of Aitipamula et al. (Cryst. Growth Des. 2012, 12, 2147-2152), we present a feasible classification system for all multicomponent crystals. The present classification enables us to analyze and classify multicomponent crystal structures present in the Cambridge Structural Database (CSD). This reveals that all seven classes proposed are relevant in terms of frequency of occurrence. Lists of CSD refcodes for all classes are provided. We identified over 5000 cocrystals in the CSD, as well as over 12 000 crystals with more than two components. This illustrates that the possibilities for alternative drug formulations can be increased significantly by considering more than two components in drug design.

ORCID iDs

Grothe, E., Meekes, H., Vlieg, E., Ter Horst, J. H. ORCID logoORCID: https://orcid.org/0000-0003-0118-2160 and De Gelder, R.;
  • Item type:Article
    ID code:56726
    Dates:
    Date
    Event
    1 June 2016
    Published
    21 April 2016
    Published Online
    13 April 2016
    Accepted
    Notes:This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
    Subjects:UNSPECIFIED
    Department:University of Strathclyde > University of Strathclyde
    Depositing user: Pure Administrator
    Date deposited:23 Jun 2016 08:53
    Last modified:21 Nov 2024 01:12
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/56726
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