Developing and understanding biofluid vibrational spectroscopy : a critical review

Baker, Matthew J. and Hussain, Shawn R. and Lovergne, Lila and Untereiner, Valérie and Hughes, Caryn and Lukaszewski, Roman A. and Thiéfin, Gérard and Sockalingum, Ganesh D. (2015) Developing and understanding biofluid vibrational spectroscopy : a critical review. Chemical Society Reviews, 45 (7). pp. 1785-2002. ISSN 0306-0012 (

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Vibrational spectroscopy can provide rapid, label-free, and objective analysis for the clinical domain. Spectroscopic analysis of biofluids such as blood components (e.g. serum and plasma) and others in the proximity of the diseased tissue or cell (e.g. bile, urine, and sputum) offers non-invasive diagnostic/monitoring possibilities for future healthcare that are capable of rapid diagnosis of diseases via specific spectral markers or signatures. Biofluids offer an ideal diagnostic medium due to their ease and low cost of collection and daily use in clinical biology. Due to the low risk and in vasiveness of their collection they are widely welcomed by patients as a diagnostic medium. This review under scores recent research within the field of biofluid spectroscopy and its use in myriad pat hologies such as cancer and infectious diseases. It highlights current progresses, advents, and pitfalls within the field and discusses future spectroscopic clinical potentials for diagnostics. The requirements and issues surrounding clinical translation are also considered.