Proteinase-activated receptor 2 is involved in the behavioural changes associated with sickness behaviour

Abulkassim, Roua and Brett, Ros and MacKenzie, Scott M. and Bushell, Trevor J. (2016) Proteinase-activated receptor 2 is involved in the behavioural changes associated with sickness behaviour. Journal of Neuroimmunology, 295-296. pp. 139-147. ISSN 0165-5728

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    Abstract

    Proteinase-activated receptor-2 (PAR2) is widely expressed in the CNS but whether it plays a key role in inflammation-related behavioural changes remains unknown. Hence, in the present study we have examined whether PAR2 contributes to behaviour associated with systemic inflammation using PAR2 transgenic mice. The onset of sickness behaviour was delayed and the recovery accelerated in PAR2-/- mice in the LPS-induced model of sickness behaviour. In contrast, PAR2 does not contribute to behaviour under normal conditions. In conclusion, these data suggest that PAR2 does not contribute to behaviour in the normal healthy brain but it plays a role in inflammation-related behavioural changes.

    Creators(s): Abulkassim, Roua, Brett, Ros, MacKenzie, Scott M. and Bushell, Trevor J. ORCID logoORCID: https://orcid.org/0000-0003-4145-9670;
    Item type:Article
    ID code:56231
    Keywords:proteinase-activated receptor-2, LPS, sickness behaviour, locomotor activity, anxiety, sucrose preference, Pharmacy and materia medica, Neuroscience(all)
    Subjects:Medicine > Pharmacy and materia medica
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Depositing user: Pure Administrator
    Date deposited:28 Apr 2016 13:50
    Last modified:01 Mar 2021 01:37
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/56231
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