Electrochemiluminescence platform for the detection of C-reactive proteins : application of recombinant antibody technology to cardiac biomarker detection

O'Reilly, Emmet J. and Conroy, Paul J. and Hearty, Stephen and Keyes, Tia E. and O'Kennedy, Richard and Forster, Robert J. and Dennany, Lynn (2015) Electrochemiluminescence platform for the detection of C-reactive proteins : application of recombinant antibody technology to cardiac biomarker detection. RSC Advances, 5 (83). pp. 67874-67877. ISSN 2046-2069 (https://doi.org/10.1039/C5RA08450D)

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Abstract

This work exploits the high-affinity of recombinant antibodies and low background electrochemiluminescence (ECL) for cardiac-biomarker detection. The developed assay is capable of fg mL-1 detection limits as well as the detection of C-Reactive Protein (CRP) over a clinically relevant range. The assay demonstrated robust reproducibility, selectivity and stability while also highlighting a novel platform for detection of cardiac biomarkers at low concentrations.

ORCID iDs

Dennany, Lynn ORCID: https://orcid.org/0000-0002-5481-1066

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• Item metadata

  Item type:	Article
  ID code:	55990
  Dates:	Date Event 31 July 2015 Published 31 July 2015 Accepted
  Subjects:	Science > Chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry
  Depositing user:	Pure Administrator
  Date deposited:	23 Mar 2016 14:30
  Last modified:	12 Dec 2024 03:31
  URI:	https://strathprints.strath.ac.uk/id/eprint/55990