Isatin thiosemicarbazone-blended polymer films for biomedical applications : surface morphology, characterisation and preliminary biological assessment

Mallinson, David and Alexiou, Polyxeni and Mullen, Alexander B. and Pelecanou, Maria and Sagnou, Marina and Lamprou, Dimitrios A. (2016) Isatin thiosemicarbazone-blended polymer films for biomedical applications : surface morphology, characterisation and preliminary biological assessment. RSC Advances. ISSN 2046-2069

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    Abstract

    Poly (methyl methacrylate) and polyurethane are polymers currently used for a range of biomedical applications. To modify their surface characteristics, biocompatibility and potentially reduce any related side effects the addition to the polymers of appropriate compounds has been investigated. Isatin thiosemicarbazone derivatives were synthesised and added to poly (methyl methacrylate) and polyurethane solutions before spin coating them on to a silica wafer. The resultant films were characterised with contact angle goniometry and atomic force microscopy. PMMA films produced from tetrahydrofuran solvent displayed honeycombed structures which were highly hydrophobic; however, such changes were not seen for polyurethane surfaces. The cytotoxicity and effect on cell proliferation of polymer surfaces were investigated using PNT2A prostate cells. The isatin-containing polymers were deemed non-toxic at the concentrations used, while cell proliferation studies suggested that the resulting films were supportive of cell growth.

    Creators(s): Mallinson, David ORCID logoORCID: https://orcid.org/0000-0003-2615-633X, Alexiou, Polyxeni, Mullen, Alexander B. ORCID logoORCID: https://orcid.org/0000-0001-7475-5543, Pelecanou, Maria, Sagnou, Marina and Lamprou, Dimitrios A. ORCID logoORCID: https://orcid.org/0000-0002-8740-1661;
    Item type:Article
    ID code:55739
    Keywords:polyurethane, Isatin thiosemicarbazone, polymer surfaces, cell growth, Chemistry, Chemical Engineering(all), Chemistry(all)
    Subjects:Science > Chemistry
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Technology and Innovation Centre > Continuous Manufacturing and Crystallisation (CMAC)
    Depositing user: Pure Administrator
    Date deposited:03 Mar 2016 10:30
    Last modified:14 Feb 2020 00:50
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/55739
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