Synthesis of DNA-sequence-selective hairpin polyamide platinum complexes
Taleb, R.I. and Jaramillo, D. and Wheate, N.J. and Aldrich-Wright, J.R. (2007) Synthesis of DNA-sequence-selective hairpin polyamide platinum complexes. Chemistry - A European Journal, 13. pp. 3177-3186. ISSN 0947-6539
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Two DNA-sequence-selective hairpin polyamide platinum(II) complexes, containing pyrrole and imidazole heterocyclic rings, have been synthesised by different methods. A six-ring complex, selective for (A/T)GGG(A/T) DNA sequences, was made by using solid-phase synthesis, whilst an eight-ring complex, selective for (A/T)CCTG(A/T) DNA sequences, was made by utilising standard wet chemistry. Solid-phase synthesis resulted in a significantly higher yield, required less purification and is more efficient than the wet synthesis; as such, it is the preferred method for further work. The metal complexes were characterised by 1H and 195Pt NMR spectroscopy and ESI mass spectrometry. The two compounds provide a foundation for the synthesis of more complex molecules containing multiple hairpins and/or platinum groups.
Creators(s): | Taleb, R.I., Jaramillo, D., Wheate, N.J. and Aldrich-Wright, J.R.; | Item type: | Article |
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ID code: | 5480 |
Keywords: | antitumor agents, DNA recognition, platinum, polyamides, synthesis design, cancer, Pharmacy and materia medica, Chemistry(all) |
Subjects: | Medicine > Pharmacy and materia medica |
Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
Depositing user: | Strathprints Administrator |
Date deposited: | 27 Feb 2008 |
Last modified: | 05 Feb 2021 03:33 |
URI: | https://strathprints.strath.ac.uk/id/eprint/5480 |
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