Picture of model of urban architecture

Open Access research that is exploring the innovative potential of sustainable design solutions in architecture and urban planning...

Strathprints makes available scholarly Open Access content by researchers in the Department of Architecture based within the Faculty of Engineering.

Research activity at Architecture explores a wide variety of significant research areas within architecture and the built environment. Among these is the better exploitation of innovative construction technologies and ICT to optimise 'total building performance', as well as reduce waste and environmental impact. Sustainable architectural and urban design is an important component of this. To this end, the Cluster for Research in Design and Sustainability (CRiDS) focuses its research energies towards developing resilient responses to the social, environmental and economic challenges associated with urbanism and cities, in both the developed and developing world.

Explore all the Open Access research of the Department of Architecture. Or explore all of Strathclyde's Open Access research...

In vitro correlates of Ld-restricted resistance to toxoplasmic encephalitis and their critical dependence on parasite strain

Johnson, Jennifer J and Roberts, Craig W and Pope, Constance and Roberts, Fiona and Kirisits, Michael J and Estes, Randee and Mui, Ernest and Krieger, Tim and Brown, Charles R and Forman, Jim and McLeod, Rima (2002) In vitro correlates of Ld-restricted resistance to toxoplasmic encephalitis and their critical dependence on parasite strain. Journal of Immunology, 169 (2). pp. 966-973. ISSN 0022-1767

Full text not available in this repository. Request a copy from the Strathclyde author


Resistance to murine toxoplasmic encephalitis has been precisely and definitively mapped to the L(d) class I gene. Consistent with this, CD8(+) T cells can adoptively transfer resistance to toxoplasmic encephalitis. However, cytotoxic CD8(+) T cells, capable of killing class I-matched, infected target cells, are generated during the course of Toxoplasma gondii infection even in mice lacking the L(d) gene. L(d)-restricted killing could not be demonstrated, and the functional correlate of the L(d) gene has therefore remained elusive. Herein, L(d)-restricted killing of T. gondii-infected target cells is demonstrated for the first time. L(d)-restricted killing is critically dependent on the strain of T. gondii and is observed with all the derivatives of type II strains tested, but not with a type I strain. These results have important implications for vaccine development.