In vitro correlates of Ld-restricted resistance to toxoplasmic encephalitis and their critical dependence on parasite strain

Johnson, Jennifer J and Roberts, Craig W and Pope, Constance and Roberts, Fiona and Kirisits, Michael J and Estes, Randee and Mui, Ernest and Krieger, Tim and Brown, Charles R and Forman, Jim and McLeod, Rima (2002) In vitro correlates of Ld-restricted resistance to toxoplasmic encephalitis and their critical dependence on parasite strain. Journal of Immunology, 169 (2). pp. 966-973. ISSN 0022-1767

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Abstract

Resistance to murine toxoplasmic encephalitis has been precisely and definitively mapped to the L(d) class I gene. Consistent with this, CD8(+) T cells can adoptively transfer resistance to toxoplasmic encephalitis. However, cytotoxic CD8(+) T cells, capable of killing class I-matched, infected target cells, are generated during the course of Toxoplasma gondii infection even in mice lacking the L(d) gene. L(d)-restricted killing could not be demonstrated, and the functional correlate of the L(d) gene has therefore remained elusive. Herein, L(d)-restricted killing of T. gondii-infected target cells is demonstrated for the first time. L(d)-restricted killing is critically dependent on the strain of T. gondii and is observed with all the derivatives of type II strains tested, but not with a type I strain. These results have important implications for vaccine development.

Creators(s): Johnson, Jennifer J, Roberts, Craig W ORCID logoORCID: https://orcid.org/0000-0002-0653-835X, Pope, Constance, Roberts, Fiona, Kirisits, Michael J, Estes, Randee, Mui, Ernest, Krieger, Tim, Brown, Charles R, Forman, Jim and McLeod, Rima;
Item type:Article
ID code:5476
Keywords:animals, antigens, protozoan, cells, cultured, cytotoxicity, immunologic, encephalitis, female, H-2 antigens, histocompatibility antigen H-2D, humans, immunity, innate, interferon-gamma, lymphocyte activation, male, mice, mice, inbred BALB C, mice, i`nbred C3H, mice, transgenic, species specificity, spleen, T-lymphocytes, cytotoxic, toxoplasma, toxoplasmosis, animal, virulence, Pharmacy and materia medica, Therapeutics. Pharmacology, Pharmacology, Toxicology and Pharmaceutics(all)
Subjects:Medicine > Pharmacy and materia medica
Medicine > Therapeutics. Pharmacology
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Engineering > Architecture
Depositing user: Strathprints Administrator
Date deposited:27 Feb 2008
Last modified:02 Sep 2020 01:14
URI:https://strathprints.strath.ac.uk/id/eprint/5476
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