In vitro correlates of Ld-restricted resistance to toxoplasmic encephalitis and their critical dependence on parasite strain
Johnson, Jennifer J and Roberts, Craig W and Pope, Constance and Roberts, Fiona and Kirisits, Michael J and Estes, Randee and Mui, Ernest and Krieger, Tim and Brown, Charles R and Forman, Jim and McLeod, Rima (2002) In vitro correlates of Ld-restricted resistance to toxoplasmic encephalitis and their critical dependence on parasite strain. Journal of Immunology, 169 (2). pp. 966-973. ISSN 0022-1767
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Resistance to murine toxoplasmic encephalitis has been precisely and definitively mapped to the L(d) class I gene. Consistent with this, CD8(+) T cells can adoptively transfer resistance to toxoplasmic encephalitis. However, cytotoxic CD8(+) T cells, capable of killing class I-matched, infected target cells, are generated during the course of Toxoplasma gondii infection even in mice lacking the L(d) gene. L(d)-restricted killing could not be demonstrated, and the functional correlate of the L(d) gene has therefore remained elusive. Herein, L(d)-restricted killing of T. gondii-infected target cells is demonstrated for the first time. L(d)-restricted killing is critically dependent on the strain of T. gondii and is observed with all the derivatives of type II strains tested, but not with a type I strain. These results have important implications for vaccine development.
| Author(s): | Johnson, Jennifer J, Roberts, Craig W, Pope, Constance, Roberts, Fiona, Kirisits, Michael J, Estes, Randee, Mui, Ernest, Krieger, Tim, Brown, Charles R, Forman, Jim and McLeod, Rima | Item type: | Article |
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| ID code: | 5476 |
| Keywords: | animals, antigens, protozoan, cells, cultured, cytotoxicity, immunologic, encephalitis, female, H-2 antigens, histocompatibility antigen H-2D, humans, immunity, innate, interferon-gamma, lymphocyte activation, male, mice, mice, inbred BALB C, mice, i`nbred C3H, mice, transgenic, species specificity, spleen, T-lymphocytes, cytotoxic, toxoplasma, toxoplasmosis, animal, virulence, Pharmacy and materia medica, Therapeutics. Pharmacology, Pharmacology, Toxicology and Pharmaceutics(all) |
| Subjects: | Medicine > Pharmacy and materia medica Medicine > Therapeutics. Pharmacology |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Faculty of Engineering > Architecture |
| Depositing user: | Strathprints Administrator |
| Date deposited: | 27 Feb 2008 |
| Last modified: | 30 Jan 2019 08:39 |
| URI: | https://strathprints.strath.ac.uk/id/eprint/5476 |
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