Isotopic labelling of functionalised arenes catalysed by Ir(I) species of the [(COD)Ir(NHC)(py)]PF6 complex class

Kerr, William and Paterson, Laura and Herbert, John and McNeill, Alan and Cross, Paul (2015) Isotopic labelling of functionalised arenes catalysed by Ir(I) species of the [(COD)Ir(NHC)(py)]PF6 complex class. Synlett, 27 (1). pp. 111-115. ISSN 0936-5214

[img]
Preview
Text (Kerr-etal-Synlett-2015-Isotopic-labelling-of-functionalised-arenes-catalysed-by)
Kerr_etal_Synlett_2015_Isotopic_labelling_of_functionalised_arenes_catalysed_by.pdf
Accepted Author Manuscript

Download (1MB)| Preview

    Abstract

    Ir(I) complexes of the type [(COD)Ir(NHC)(Py)]PF6 have been exposed as efficient catalysts in the area of hydrogen isotope exchange. More specifically, via an ortho-directed C-H activation process, high levels of deuterium incorporation have been achieved using low levels of catalyst over a range of functionalised aromatic compounds. Additionally, the developed protocol has been extended to include a selected pharmacological target, where chemoselective labelling is observed within such a multifunctional substrate.