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Optimization of the geometry and porosity of microelectrode arrays for sensor design

Sandison, Mairi E. and Anicet, Natalie and Glidle, Andrew and Cooper, Jonathan M. (2002) Optimization of the geometry and porosity of microelectrode arrays for sensor design. Analytical Chemistry, 74 (22). pp. 5717-5725. ISSN 0003-2700

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Abstract

This paper describes the systematic investigation of a range of microelectrode arrays with varying dimensions fabricated by standard photolithographic and reactive-ion etching techniques. As expected from theory, the electrochemical behavior of microelectrode arrays with a constant individual diameter varied strongly with center-to-center spacing, the larger the spacing the more sigmoidal the recorded voltammogram. Furthermore, the behavior of arrays with a constant relative center-to-center spacing is shown to vary with individual electrode diameter, the arrays with the smallest electrodes producing strongly peaked voltammograms. Peak current densities and signal-to-noise ratios were also obtained for a variety of array geometries, and the use of electrodeposited platinum black electrodes was investigated. To demonstrate one advantage of using a loosely packed microelectrode array in electroanalysis, a ferrocene-mediated enzyme-linked assay involving the biocatalytic reduction of H2O2 was investigated. Results showed an improved temporal response, with current-time transients reaching a steady-state response more quickly using arrays with increased center-center spacings.

Item type: Article
ID code: 54423
Keywords: biosensing techniques, electrochemistry, enzyme-linked immunosorbent assay, indicators and reagents, microcomputers, microelectrodes, nanotechnology, Bioengineering, Analytical Chemistry
Subjects: Technology > Engineering (General). Civil engineering (General) > Bioengineering
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Engineering > Biomedical Engineering
Depositing user: Pure Administrator
Date deposited: 01 Oct 2015 13:09
Last modified: 01 Mar 2019 03:54
URI: https://strathprints.strath.ac.uk/id/eprint/54423
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